| Tissue and serum galectin-1 expression in patients with colorectal carcinoma. | |
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MedLine Citation:
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PMID: 22353504 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/Aims: To observe the expressing model of galectin-1 in colorectal carcinoma (CRC) progress. Methodology: The expression of galectin-1 in peritumor, adenoma and CRC tissues using immunohistochemistry, western-blotting and RT-PCR was detected. Serum galectin-1 concentrations were detected by ELISA. Results: Galectin-1 intensities in peritumor, adenoma and CRC tissues increased serially. Galectin- 1 expressed in the extracellular matrix of peritumor and pathological colorectal tissues mainly, while almost none was detected in colorectal epithelia. Different colorectal tissues expressed galectin-1 with different intensities. Non-parametric tests showed increased galectin-1 intensities were in peritumor, adenoma and carcinoma tissues (p<0.001). The over-expressing rates of galectin-1 in CRCs from Dukes A to D stage were increased significantly (p<0.001). Differently expressing intensities of galectin-1 were in different invasive locations of CRCs. RT-PCR showed that no statistically significant differences of galectin-1 mRNA were observed among peritumor colorectal tissue, adenoma and CRC tissues (p>0.05). Serum concentrations of galectin-1 decreased from healthy individuals to Dukes D CRCs. The differences between any of the groups were significant (p<0.05). Conclusions: Stronger intensities of galectin-1 protein in the extracellular matrix of CRC tissues than those of peritumor and adenoma tissues, with no significant differences in the mRNA levels of galectin-1. Interestingly, serum galectin- 1 concentrations in patients with CRC decreased significantly. Above all, we presume that overexpression of galectin-1 protein in the CRCs is derived possibly from secreted galectin-1 from other normal tissues that cumulate in the stroma. |
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Authors:
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Tong-Hua Sheng; Lai-Xiao Rong; Zhang-Ya Li; Jiang Bo; Su Lei |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 59 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2012 Mar-Apr |
Date Detail:
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Created Date: 2012-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 389-94 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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