| Tissue restoration after resorption of polyglycolide and poly-laevo-lactic acid screws. | |
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MedLine Citation:
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PMID: 16260683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite worldwide clinical use of bio-absorbable devices for internal fixation in orthopaedic surgery, the degradation behaviour and tissue replacement of these implants are not fully understood. In a long-term experimental study, we have determined the patterns of tissue restoration 36 and 54 months after implantation of polyglycolic acid and poly-laevo-lactic acid screws in the distal femur of the rabbit. After 36 months in the polyglycolic acid group the specimens showed no remaining polymer and loose connective tissue occupied 80% of the screw track. Tissue restoration remained poor at 54 months, the amounts of trabecular bone and haematopoietic elements being significantly lower than those in the intact control group. The amount of trabecular bone within the screw track at 54 months in the polyglycolic acid group was less than in the empty drill holes (p = 0.04). In the poly-laevo-lactic acid group, polymeric material was present in abundance after 54 months, occupying 60% of the cross-section of the core area of the screw track. When using absorbable internal fixation implants we should recognise that the degradation of the devices will probably not be accompanied by the restoration of normal trabecular bone. |
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Authors:
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O M Böstman; O M Laitinen; O Tynninen; S T Salminen; H K Pihlajamäki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of bone and joint surgery. British volume Volume: 87 ISSN: 0301-620X ISO Abbreviation: J Bone Joint Surg Br Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2005-12-13 Revised Date: 2010-11-10 |
Medline Journal Info:
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Nlm Unique ID: 0375355 Medline TA: J Bone Joint Surg Br Country: England |
Other Details:
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Languages: eng Pagination: 1575-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Orthopaedics and Trauma Surgery, Helsinki University Hospital, P. O. Box 266, FIN-00029, Helsinki, Finland. Ole.Bostman@Helsinki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Adipose Tissue / pathology Animals Biocompatible Materials Bone Regeneration* Bone Screws* Bone and Bones / pathology Connective Tissue / pathology Female Fracture Fixation, Internal / instrumentation, methods Hematopoiesis Internal Fixators Lactic Acid / analogs & derivatives*, chemistry Male Polyglycolic Acid / chemistry* Polymers / chemistry* Postoperative Period Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polymers; 0/polylevolactic acid; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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