Document Detail

Tissue responses to endovascular stent grafts for saccular abdominal aortic aneurysms in a canine model.
MedLine Citation:
PMID:  23091313     Owner:  NLM     Status:  MEDLINE    
We investigated tissue responses to endoskeleton stent grafts for saccular abdominal aortic aneurysms (AAAs) in canines. Saccular AAAs were made with Dacron patch in 8 dogs, and were excluded by endoskeleton stent grafts composed of nitinol stent and expanded polytetrafluoroethylene graft. Animals were sacrificed at 2 months (Group 1; n = 3) or 6 months (Group 2; n = 5) after the placement, respectively. The aortas embedding stent grafts were excised en bloc for gross inspection and sliced at 5 to 8 mm intervals for histopathologic evaluation. Stent grafts were patent in all except a dog showing a thrombotic occlusion in Group 2. In the 7 dogs with patent lumen, the graft overhanging the saccular aneurysm was covered by thick or thin thrombi with no endothelial layer, and the graft over the aortic wall was completely covered by neointima with an endothelial layer. Transgraft cell migration was less active at an aneurysm than at adjacent normal aorta. In conclusion, endoskeleton stent grafts over saccular aneurysms show no endothelial coverage and poor transgraft cell migration in a canine model.
Hyun Beom Kim; Young Ho Choi; Young Ho So; Seung-Kee Min; Hyo-Cheol Kim; Young Il Kim; Jae Hyung Park; Jin Wook Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Journal of Korean medical science     Volume:  27     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-05-09     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1170-6     Citation Subset:  IM    
Department of Radiology, National Cancer Center, Goyang, Korea.
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MeSH Terms
Alloys / chemistry
Aortic Aneurysm, Abdominal / pathology*,  surgery,  ultrasonography
Cell Movement
Disease Models, Animal
Endothelial Cells / cytology
Neointima / etiology
Polytetrafluoroethylene / chemistry
Thrombosis / etiology
Tomography, X-Ray Computed
Reg. No./Substance:
0/Alloys; 52013-44-2/nitinol; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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