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Tissue rescue therapy for acute ischaemic stroke.
MedLine Citation:
PMID:  18638777     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Despite population-based declines in stroke mortality, the individual mortality rate in ischaemic stroke approaches 20%, with substantial morbidity in the majority of survivors. Reduction of this rate will depend on the advent of effective acute tissue rescue therapy. Based on improved understanding of the pathophysiology of acute ischaemia, it is now recognised that the time window for therapeutic intervention is only a few hours after stroke onset. The major therapeutic strategies currently being investigated include firstly approaches to improve reperfusion after ischaemia, such as thrombolysis, haemorheological and antithrombotic therapies, and secondly strategies for neuronal protection such as calcium channel and NMDA antagonists and free radical inhibitors. Based on promising animal and early human studies, the results of large randomised, placebo-controlled clinical trials are expected in the near future and should have a profound effect on acute stroke management.
Authors:
S M Davis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  2     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  1995 Jan 
Date Detail:
Created Date:  2008-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  7-15     Citation Subset:  -    
Affiliation:
Department of Neurology, Clinical Neuroscience Centre, Royal Melbourne Hospital, Victoria, Australia.
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