Document Detail

Tissue repair: The hidden drama.
MedLine Citation:
PMID:  21220961     Owner:  NLM     Status:  MEDLINE    
As living beings who encounter every kind of traumatic event from paper cut to myocardial infarction, we must possess ways to heal damaged tissues. While some animals are able to regrow complete body parts following injury (such as the earthworm who grows a new head following bisection), humans are sadly incapable of such feats. Our means of recovery following tissue damage consists largely of repair rather than pure regeneration. Thousands of times in our lives, a meticulously scripted but unseen wound healing drama plays, with cells serving as actors, extracellular matrix as the setting, and growth factors as the means of communication. This article briefly reviews the cells involved in tissue repair, their signaling and proliferation mechanisms, and the function of the extracellular matrix, then presents the actors and script for the three acts of the tissue repair drama.
Kristine P Krafts
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Organogenesis     Volume:  6     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-06-06     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Department of Pathology, University of Minnesota School of Medicine, Duluth Campus, Duluth, MN, USA.
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MeSH Terms
Extracellular Matrix / metabolism*
Intercellular Signaling Peptides and Proteins / metabolism
Signal Transduction
Stem Cells / cytology,  metabolism
Wound Healing*
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins

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