| Tissue renin-angiotensin system in myocardial hypertrophy and failure. | |
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MedLine Citation:
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PMID: 8386920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin system traditionally has been conceived as a neuroendocrine system functioning in the circulation. Recent research has confirmed the existence of autocrine/paracrine tissue renin-angiotensin systems present and functioning at multiple sites, including cardiac, vascular, and renal tissues, which contain the majority of angiotensin-converting enzyme in the body. It appears that the circulating renin-angiotensin system is activated acutely to maintain homeostasis and is then turned off at cardiovascular compensation, while the tissue renin-angiotensin systems exert long-term actions that affect cardiovascular function and structure, which may play a pathophysiological role in congestive heart failure, hypertension, and vascular disease and influence the response to therapy with angiotensin-converting enzyme-inhibiting agents. |
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Authors:
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V J Dzau |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Archives of internal medicine Volume: 153 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-24 Completed Date: 1993-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 937-42 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Medicine, Stanford University Medical Center, Calif. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomegaly / physiopathology* Heart Failure / physiopathology* Humans Peptidyl-Dipeptidase A / physiology* Renin-Angiotensin System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL35252/HL/NHLBI NIH HHS; HL35610/HL/NHLBI NIH HHS; HL42663/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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