Document Detail


Tissue renin-angiotensin system in myocardial hypertrophy and failure.
MedLine Citation:
PMID:  8386920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renin-angiotensin system traditionally has been conceived as a neuroendocrine system functioning in the circulation. Recent research has confirmed the existence of autocrine/paracrine tissue renin-angiotensin systems present and functioning at multiple sites, including cardiac, vascular, and renal tissues, which contain the majority of angiotensin-converting enzyme in the body. It appears that the circulating renin-angiotensin system is activated acutely to maintain homeostasis and is then turned off at cardiovascular compensation, while the tissue renin-angiotensin systems exert long-term actions that affect cardiovascular function and structure, which may play a pathophysiological role in congestive heart failure, hypertension, and vascular disease and influence the response to therapy with angiotensin-converting enzyme-inhibiting agents.
Authors:
V J Dzau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Archives of internal medicine     Volume:  153     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-24     Completed Date:  1993-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  937-42     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiovascular Medicine, Stanford University Medical Center, Calif.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / physiopathology*
Heart Failure / physiopathology*
Humans
Peptidyl-Dipeptidase A / physiology*
Renin-Angiotensin System / physiology*
Grant Support
ID/Acronym/Agency:
HL35252/HL/NHLBI NIH HHS; HL35610/HL/NHLBI NIH HHS; HL42663/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Abnormal expression of glucose-6-phosphatase in preterm infants.
Next Document:  Comparative effects of different antihypertensive treatments on progression of diabetic renal diseas...