Document Detail

Tissue remodeling of rat pulmonary artery in hypoxic breathing. I. Changes of morphology, zero-stress state, and gene expression.
MedLine Citation:
PMID:  11501619     Owner:  NLM     Status:  MEDLINE    
The remodeling of the pulmonary arterial tissue in response to a step change of the oxygen concentration in the gas in which a rat lives was recorded as function of time and function of O2 concentration. Three steps of changing from 20.9% to 17.2%, 13.6%, and 10% O2 were imposed. Earlier work in our laboratory has shown that pulmonary arterial tissue remodeling is significant in the first 24 h after a step change of oxygen tension. Hence we made measurements in this period. Furthermore, data were obtained for tissue remodeling of circumferential and axial lengths of the pulmonary arteries. We recorded the activities of gene expressions in the lung tissues by microarray, determined the dose response curves of gene expression in the homogenized whole lungs with respect to four levels of O2 concentration, and obtained the time courses of gene expression in the lung parenchyma in 30 days after a step decrease of O2 concentration from 20.9% to 10%. We would like to suggest that the correlation of gene expression with physiological function parameters, i.e., time, O2 tension, blood pressure, opening angle, wall thicknesses, etc., is the way to narrow down the search for specific genes for specific physiological functions.
W Huang; Y P Sher; D Delgado-West; J T Wu; K Peck; Y C Fung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  29     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-14     Completed Date:  2002-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-51     Citation Subset:  IM    
Department of Bioengineering, University of California San Diego, La Jolla, 92093-0412, USA.
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MeSH Terms
Anoxia / complications,  genetics,  pathology*,  physiopathology
Biomedical Engineering
Blood Pressure
Gene Expression Profiling
Hypertension, Pulmonary / etiology,  genetics,  pathology,  physiopathology
Oligonucleotide Array Sequence Analysis
Pulmonary Artery / pathology*,  physiopathology
Rats, Sprague-Dawley
Time Factors
Grant Support
Reg. No./Substance:

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