Document Detail

Tissue reactivity to poliglecaprone 25 in the feline linea alba.
MedLine Citation:
PMID:  10582744     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To use poliglecaprone 25 for all ligations and closure in routine feline ovariohysterectomies and evaluate maintenance of tissue approximation and tissue reaction to the suture.
STUDY DESIGN: Prospective, descriptive study.
ANIMALS: Twenty four female cats.
METHODS: Ovariohysterectomies were performed in all cats. Abdominal incisions were inspected on days 1, 3, 7, 14, and 28 for dehiscence and swelling. All cats were euthanatized postoperatively, group 1 on day 7; group 2 on day 14; and group 3 on day 28. The peritoneal cavity was inspected for adhesions and all abdominal incisions were collected en bloc. Each linea alba was histologically evaluated and the inflammatory reaction was characterized.
RESULTS: Dehiscence did not occur in any of the 24 cats. The incisional swelling on day 1 was significantly smaller than on day 7, and the swelling on day 14 was significantly smaller than on days 1, 3, and 7 (P < .05). Intra-abdominal adhesions were found in all groups with the greatest number associated with the peritoneum at the incision site. Tissue reactions in group 1 were pyogranulomatous or fibromononuclear, group 2 were granulomatous or fibromononuclear, and group 3 were pyogranulomatous, granulomatous, fibromononuclear or fibrous. Eosinophilic infiltration was seen in 3 of the 8 cats in group 1.
CONCLUSIONS: Incisional swelling and inflammatory reactions seen with poliglecaprone 25 were consistent with those anticipated after implantation of suture in a surgically created wound.
CLINICAL RELEVANCE: Poliglecaprone 25 appears to be an acceptable suture for use in feline ovariohysterectomy. It causes a relatively short-lived inflammatory response.
A Runk; S W Allen; E A Mahaffey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  28     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-71     Citation Subset:  IM    
Department of Small Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, USA.
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MeSH Terms
Cats / surgery*
Dioxanes / adverse effects*
Hysterectomy / methods,  veterinary
Inflammation / chemically induced,  veterinary
Ovariectomy / veterinary
Peritoneal Diseases / veterinary
Polyesters / adverse effects*
Postoperative Period
Prospective Studies
Skin / drug effects*,  pathology
Surgical Wound Dehiscence / veterinary
Suture Techniques / veterinary
Sutures / veterinary*
Tissue Adhesions / veterinary
Reg. No./Substance:
0/Dioxanes; 0/Polyesters; 41706-81-4/glycolide E-caprolactone copolymer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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