Document Detail

Tissue reaction to implanted biomaterials.
MedLine Citation:
PMID:  3858534     Owner:  NLM     Status:  MEDLINE    
Tissue reactions to the single-crystal sapphire, titanium, Co-Cr-Mo alloy, and PMMA were histologically evaluated after implantation into the subcutaneous tissue and tibia of rats. In subcutaneous tissue the reaction from early necrotic change and acute inflammation to final encapsulation by fibrous connective tissue was least pronounced around single-crystal sapphire implants. Tissue reactions of a slightly greater degree were found around titanium and Co-Cr-Mo alloy implants. The most prominent tissue reaction was observed around PMMA implants. In the tibia, single-crystal sapphire, titanium, and Co-Cr-Mo alloy implants were encapsulated by newly formed compact bone, but bone was not so evident around PMMA implants. These findings suggest that single-crystal sapphire implants have more favorable tissue compatibility than those of titanium, Co-Cr-Mo alloy, and PMMA.
Y Akagawa; M Hashimoto; N Kondo; A Yamasaki; H Tsuru
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of prosthetic dentistry     Volume:  53     ISSN:  0022-3913     ISO Abbreviation:  J Prosthet Dent     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-24     Completed Date:  1985-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376364     Medline TA:  J Prosthet Dent     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-6     Citation Subset:  D; IM    
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MeSH Terms
Aluminum Oxide / adverse effects
Biocompatible Materials*
Chromium Alloys / adverse effects
Methylmethacrylates / adverse effects
Prostheses and Implants / adverse effects*
Rats, Inbred Strains
Skin / pathology*
Tibia / pathology*
Time Factors
Titanium / adverse effects
Reg. No./Substance:
0/Biocompatible Materials; 0/Chromium Alloys; 0/Methylmethacrylates; 1344-28-1/Aluminum Oxide; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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