| Tissue protein synthesis rates in critically ill patients. | |
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MedLine Citation:
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PMID: 9428549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aims of this study were to simultaneously determine the in vivo rates of protein synthesis in skeletal muscle, peripheral blood lymphocytes, and serum albumin in critically ill patients; to establish whether a relationship between the responses of these tissues could be observed; and to demonstrate if a protein synthesis pattern characteristic of critical illness exists. DESIGN: Descriptive study. SETTING: Intensive care unit of a 1000-bed university hospital. PATIENTS: Fifteen patients treated in the intensive care unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Rates of tissue protein synthesis were determined in vivo once during the course of critical illness, using the flooding method with L-(2H5)phenylalanine. Protein synthesis in muscle was 1.49 +/- 0.16%/day; in circulating lymphocytes (i.e., mononuclear cells), protein synthesis was 11.10 +/- 1.82%/day. Albumin synthesis was 12.81 +/- 1.23%/day when expressed as the fractional rate, and was 184 +/- 19 mg/kg/day when expressed as the absolute rate. CONCLUSIONS: The individual tissues responded differently to trauma, and showed a wide range of values. The responses were not significantly correlated with each other and no pattern of tissue protein synthesis characteristic of critical illness was observed. However, both muscle protein and albumin synthesis rates correlated with metabolic status and clinical indices of the severity of illness. |
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Authors:
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P Essén; M A McNurlan; L Gamrin; K Hunter; G Calder; P J Garlick; J Wernerman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 26 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-01-28 Completed Date: 1998-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 92-100 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Intensive Care, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Glucose / metabolism C-Reactive Protein / metabolism Creatinine / blood Critical Illness* Female Gas Chromatography-Mass Spectrometry Humans Intensive Care Units Lymphocytes / metabolism Male Middle Aged Muscle Proteins / biosynthesis* Muscle, Skeletal / metabolism* Phenylalanine / diagnostic use Regression Analysis Serum Albumin / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Muscle Proteins; 0/Serum Albumin; 60-27-5/Creatinine; 63-91-2/Phenylalanine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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