Document Detail


Tissue platinum after clinical treatment with cisplatin or carboplatin in tumor-bearing patients.
MedLine Citation:
PMID:  9363322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue platinum (Pt) levels were measured in tumor-bearing patients treated with either cisplatin or carboplatin. Cisplatin was given by intra-arterial, intraperitoneal, and intravenous (iv) administrations. After death, vertebrae and intervertebral disks were removed from eight human subjects, and livers and kidneys were removed from the half of them. When cisplatin was administered intraperitoneally, Pt of the liver was higher than that of the kidney, and a high content of Pt was detected in the vertebra by comparing with the other administration methods. At the intra-arterial administration of cisplatin, Pt was mainly accumulated in the kidney. At the iv administration of cisplatin, a high level of Pt was found in the vertebra and intervertebral disk, especially at the highest value at 10.31 micrograms/g in the intervertebral disk of one case, whereas a low level of Pt was detected in the liver. On the contrary, it was found that the iv administration of carboplatin did not result in high accumulations of Pt in the liver, kidney, intervertebral disk, and vertebra. Therefore, Pt is accumulated in different organs, depending on the way cisplatin is administered, but Pt is accumulated least in them by the administration of carboplatin.
Authors:
T Minami; Y Tohno; S Tohno; M Utsumi; M Yamada; K Hashii; I Tateyama; E Kadota; Y Okazaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  58     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents / pharmacokinetics*,  therapeutic use
Bone and Bones / metabolism
Carboplatin / pharmacokinetics*,  therapeutic use
Cisplatin / pharmacokinetics*,  therapeutic use
Female
Humans
Kidney / metabolism
Liver / metabolism
Male
Middle Aged
Neoplasms / drug therapy*,  metabolism
Platinum / metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin; 41575-94-4/Carboplatin; 7440-06-4/Platinum

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