| Tissue plasminogen activator to treat impending pupillary block glaucoma in patients with acute fibrinous HLA-B27 positive iridocyclitis. | |
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MedLine Citation:
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PMID: 10704553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report the use of intracameral tissue plasminogen activator to dissolve fibrinous membranes and break posterior synechiae in patients with acute HLA-B27-positive iridocyclitis with impending pupillary block. METHODS: Two patients with severe acute fibrinous iridocyclitis and seclusio pupillae were identified. Because of the concern of impending pupillary block, intracameral tissue plasminogen activator (12.5 microg in 0.1 ml, Activase; Genentech, Inc, South San Francisco, California) was injected with a 25-gauge needle through the corneal limbus. RESULTS: Both patients showed complete dissolution of fibrin with disruption of posterior synechiae. There were no adverse events after injection. Neither patient required further invasive intervention, and both fully recovered with medical management. CONCLUSIONS: Intracameral tissue plasminogen activator is a safe and effective agent for patients with severe acute iridocyclitis and pupillary seclusion. Patients with clinical signs suggestive of impending pupillary block glaucoma may be considered for tissue plasminogen activator injection to avoid the possible need for emergency surgical iridectomy and synechiolysis. |
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Authors:
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C A Skolnick; R G Fiscella; H H Tessler; D A Goldstein |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 129 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-04 Completed Date: 2000-04-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 363-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, IL 60612-7243, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Fibrin / drug effects Fibrinolysis / drug effects Fibrinolytic Agents / therapeutic use* Glaucoma / etiology, pathology, prevention & control* HLA-B27 Antigen / analysis* Humans Iridocyclitis / blood, complications* Male Pupil Disorders / etiology, pathology, prevention & control* Tissue Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/HLA-B27 Antigen; 9001-31-4/Fibrin; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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