Document Detail

Tissue plasminogen activator and penetrating keratoplasty.
MedLine Citation:
PMID:  2116614     Owner:  NLM     Status:  MEDLINE    
We report a patient who developed severe intraocular fibrin formation following penetrating keratoplasty and vitrectomy surgery. The fibrin response worsened despite aggressive treatment with topical steroids. On the second postoperative day, 25 micrograms of intracameral tissue plasminogen activator was administered, resulting in rapid resolution of the fibrin response. The graft remained clear. We believe tissue plasminogen activator may be useful in selected cases of severe, recalcitrant postkeratoplasy fibrin formation.
D G Heidemann; G A Williams; M S Blumenkranz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmic surgery     Volume:  21     ISSN:  0022-023X     ISO Abbreviation:  Ophthalmic Surg     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0241035     Medline TA:  Ophthalmic Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-5     Citation Subset:  IM    
Department of Ophthalmology, William Beaumont Hospital, Royal Oak, Mich.
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MeSH Terms
Eye Diseases / drug therapy,  etiology*
Fibrin / metabolism
Keratoplasty, Penetrating / adverse effects*
Middle Aged
Tissue Plasminogen Activator / therapeutic use*
Vitrectomy / adverse effects*
Reg. No./Substance:
9001-31-4/Fibrin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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