| Tissue plasminogen activator in peripheral arterial thrombolysis. | |
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MedLine Citation:
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PMID: 2107957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty acute peripheral arterial thromboses in 28 patients were treated with local low-dose intra-arterial recombinant tissue plasminogen activator (t-PA). All patients received 0.5 mg h-1 t-PA and 15 also received 250 units h-1 of intra-arterial heparin. Overall limb salvage at 30 days was 83 per cent (25 out of 30 limbs). Mean(s.d.) ankle/brachial index was increased by 0.53(0.26) and there was no significant difference between the group receiving t-PA alone and that receiving t-PA and heparin. No strokes or major haemorrhages occurred but there were four (13 per cent) minor haematomas associated with the catheter entry site. There were four (13 per cent) deaths from myocardial infarction occurring between 5 and 21 days after treatment. Rethrombosis occurred in four cases (13 per cent). In two patients following t-PA alone, rethrombosis occurred after 2 and 11 days. Limb salvage was achieved with a successful repeat thrombolysis and a femoropopliteal graft respectively. Rethrombosis after t-PA and heparin occurred after 30 days in two patients due to poor run-off and extensive proximal atheromatous disease respectively. t-PA is a safe, effective thrombolytic agent when given as a low-dose intra-arterial infusion. The addition of low-dose heparin does not produce any significant benefit. |
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Authors:
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D C Berridge; R H Gregson; G S Makin; B R Hopkinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 77 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-05-03 Completed Date: 1990-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 179-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Vascular Surgery, University Hospital, Nottingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Arterial Occlusive Diseases / drug therapy* Humans Leg / blood supply Recombinant Proteins / therapeutic use Recurrence Thrombolytic Therapy* Thrombosis / drug therapy* Tissue Plasminogen Activator / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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Br J Surg. 1990 Aug;77(8):954-5
[PMID:
2118409
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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