Document Detail

Tissue morphogenesis coupled with cell shape changes.
MedLine Citation:
PMID:  20677359     Owner:  NLM     Status:  In-Process    
When different tissues successively emerge during development, they need to be morphologically segregated from each other. Morphological segregation of tissues is often accompanied by robust changes in cell shape, and these two events are precisely coordinated. We overview recent progress in understanding how such coordination is regulated at the cellular and molecular levels using vertebrate somitogenesis asa unique model. In the formation of the somitic gap and its concomitant cell epithelialization, Ephrin-Eph intercellular signals play a central role, with Ephrin transducing intracellular signals via suppression of Cdc42. These signals lead to the activation of integrin where the segment border of somites forms, which in turn induces the assembly of fibronectin, the final player for the coordination. Intimate coupling of tissue-shape and cell-shape changes is also relevant to tumor suppression.
Tadayoshi Watanabe; Yoshiko Takahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  20     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.
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