| Tissue microarray technology: principles, pitfalls and perspectives--lessons learned from hematological malignancies. | |
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MedLine Citation:
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PMID: 16125349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Detection, validation and incorporation into clinical use of new diagnostic, prognostic and therapeutic molecular targets in modern medical science should be time- and cost-efficient. Here, we discuss the principles, advantages, disadvantages and possible pitfalls of tissue microarray (TMA) technology, a powerful tool for high throughput large-scale morphological in situ analysis of molecular targets. Based on recent observations from molecular profiling of hematological malignancies, we review potential TMA applications assessing molecular targets in large collectives of tissue specimens. |
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Authors:
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Alexandar Tzankov; Philip Went; Annette Zimpfer; Stephan Dirnhofer |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Experimental gerontology Volume: 40 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2005 Aug-Sep |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2006-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 737-44 Citation Subset: IM |
Affiliation:
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The Institutes of Pathology, Medical University of Innsbruck, Muellerstr. 44, A-6020 Innsbruck, Austria. alexandar.tzankov@uibk.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Profiling* Hematologic Neoplasms / genetics* Humans Molecular Probe Techniques Neoplasm Proteins / analysis, genetics* Oligonucleotide Array Sequence Analysis* Protein Array Analysis Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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