Document Detail


Tissue microarray analysis of interleukin-20 expression.
MedLine Citation:
PMID:  16908179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Knowledge about the biological functions and clinical implications of interleukin (IL)-20, a recently discovered cytokine in the IL-10 family, is still incomplete. Our aim was to determine the distribution of IL-20 expression and to delineate the cell types that express IL-20 in healthy and neoplastic tissue, because this information will significantly affect the exploration of its pathophysiological roles. We used tissue microarray technology and an immunohistochemical survey using an anti-IL-20 monoclonal antibody to examine IL-20 expression in 36 non-neoplastic and 14 neoplastic tissues. IL-20 protein was positively stained in 30 non-neoplastic tissue types and five major cell types: epithelial cells, myoepithelial cells, endothelial cells, macrophages, and skeletal muscle cells. We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung. Our data provide valuable references for further investigation of the biological functions and clinical implications of IL-20 in humans.
Authors:
Chung-Hsi Hsing; Chung-Liang Ho; Lih-Yun Chang; Yi-Lin Lee; Shih-Sung Chuang; Ming-Shi Chang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-05
Journal Detail:
Title:  Cytokine     Volume:  35     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2006-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Affiliation:
Institute of Biopharmaceutical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Profiling
Humans
Immunohistochemistry
Interleukins / analysis,  biosynthesis*,  genetics*
Neoplasm Proteins / analysis,  biosynthesis,  genetics
Tissue Array Analysis*
Tissue Distribution / genetics
Chemical
Reg. No./Substance:
0/Interleukins; 0/Neoplasm Proteins; 0/interleukin 20

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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