| Tissue metabolism and enzyme activities in the rodent Heterocephalus glaber, a poor temperature regulator. | |
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MedLine Citation:
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PMID: 233774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Tissue oxygen uptake and enzyme activities were investigated in the naked mole rat, Heterocephalus glaber, a mammal notable for its low body temperature and metabolism and poor temperature regulating ability. 2. Q10 for O2 uptake of Heterocephalus crude liver homogenates ranged from 1.91 for the temperature interval 25-30 degrees C to 1.76 within the range 30-38 degrees C, values similar to those reported for typical homoiotherms. 3. Km pyruvate of lactate dehydrogenase in heart muscle had the same temperature dependence in the mole rat and mouse. 4. O2 uptake and cytochrome oxidase activity of skeletal muscle were higher for mole rat than mouse. The reverse was true for heart muscle. Brain and liver O2 uptake showed similar values for both species, while kidney O2 uptake was highest in the mouse. 5. Pyruvate kinase activity in heart and skeletal muscle was higher in mouse than mole rat, suggesting a greater reliance on glycolysis in the former. 6. Na+, K+ -ATPase activity of liver and kidney was 60% higher in mouse than mole rat, while brain was 30% higher in mouse. 7. The results indicate that the effects of temperature on tissue metabolism in the mole rat conform to those in typical homoiotherms. The low body temperature and O2 uptake in the mole rat find no expression in the tissue respiratory capacity. |
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Authors:
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H Gesser; K Johansen; G M Maloiy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. B, Comparative biochemistry Volume: 57 ISSN: 0305-0491 ISO Abbreviation: Comp. Biochem. Physiol., B Publication Date: 1977 |
Date Detail:
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Created Date: 1989-05-26 Completed Date: 1989-05-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984730R Medline TA: Comp Biochem Physiol B Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 293-6 Citation Subset: IM |
Affiliation:
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Department of Zoophysiology, University of Aarhus, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation* Electron Transport Complex IV / metabolism Histocytochemistry L-Lactate Dehydrogenase / metabolism Oxygen Consumption Pyruvate Kinase / metabolism Rodentia / physiology* Sodium-Potassium-Exchanging ATPase / metabolism Species Specificity |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.9.3.1/Electron Transport Complex IV; EC 2.7.1.40/Pyruvate Kinase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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