Document Detail

Tissue-mediated regeneration of ascorbic acid: is the process enzymatic?
MedLine Citation:
PMID:  1292929     Owner:  NLM     Status:  MEDLINE    
Ascorbic acid's function in animals is attributed in part to the ease with which it reduces potentially damaging components, such as reactive free radicals. After more than six decades of speculation and laboratory efforts, the mechanisms by which ascorbic acid is maintained in the useful, reduced state remain uncertain. Previous attempts to isolate the enzymes that reduce the partially and the fully oxidized metabolites of vitamin C are reviewed. Some speculation on why dehydroascorbate reductase (EC has not been purified from animal tissues is presented.
R C Rose; A M Bode
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Enzyme     Volume:  46     ISSN:  0013-9432     ISO Abbreviation:  Enzyme     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1262265     Medline TA:  Enzyme     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
Department of Physiology and Biophysics, Chicago Medical School, Ill.
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MeSH Terms
Ascorbic Acid / metabolism*
Dehydroascorbic Acid / metabolism*
Free Radicals
Oxidoreductases / metabolism
Grant Support
Reg. No./Substance:
0/Free Radicals; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid; EC 1.-/Oxidoreductases; EC dehydrogenase (ascorbate)

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