| Tissue-mediated regeneration of ascorbic acid: is the process enzymatic? | |
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MedLine Citation:
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PMID: 1292929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascorbic acid's function in animals is attributed in part to the ease with which it reduces potentially damaging components, such as reactive free radicals. After more than six decades of speculation and laboratory efforts, the mechanisms by which ascorbic acid is maintained in the useful, reduced state remain uncertain. Previous attempts to isolate the enzymes that reduce the partially and the fully oxidized metabolites of vitamin C are reviewed. Some speculation on why dehydroascorbate reductase (EC 1.8.5.1) has not been purified from animal tissues is presented. |
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Authors:
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R C Rose; A M Bode |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Enzyme Volume: 46 ISSN: 0013-9432 ISO Abbreviation: Enzyme Publication Date: 1992 |
Date Detail:
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Created Date: 1993-04-02 Completed Date: 1993-04-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1262265 Medline TA: Enzyme Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 196-203 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Chicago Medical School, Ill. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / metabolism* Dehydroascorbic Acid / metabolism* Free Radicals Humans Oxidation-Reduction Oxidoreductases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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EY 07320/EY/NEI NIH HHS; HD 20398/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid; EC 1.-/Oxidoreductases; EC 1.8.5.1/glutathione dehydrogenase (ascorbate) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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