Document Detail


Tissue-mediated regeneration of ascorbic acid: is the process enzymatic?
MedLine Citation:
PMID:  1292929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ascorbic acid's function in animals is attributed in part to the ease with which it reduces potentially damaging components, such as reactive free radicals. After more than six decades of speculation and laboratory efforts, the mechanisms by which ascorbic acid is maintained in the useful, reduced state remain uncertain. Previous attempts to isolate the enzymes that reduce the partially and the fully oxidized metabolites of vitamin C are reviewed. Some speculation on why dehydroascorbate reductase (EC 1.8.5.1) has not been purified from animal tissues is presented.
Authors:
R C Rose; A M Bode
Related Documents :
9094879 - Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smok...
17442469 - Leaf extracellular ascorbate in relation to o(3) tolerance of two soybean cultivars.
7946919 - Chromium and chronic ascorbic acid depletion effects on tissue ascorbate, manganese, an...
8379489 - Scurvy: more than historical relevance.
1578489 - 3-o-alkylascorbic acids as free radical quenchers. 3. protective effect on coronary occ...
18331769 - Protection of ash (fraxinus excelsior) trees from ozone injury by ethylenediurea (edu):...
15979459 - The glycosphingolipid receptor for vibrio trachuri in the red sea bream intestine is a ...
18602549 - Home-made capillary array electrophoresis for high-throughput amino acid analysis.
18622179 - Gamma-hydroxybutyric acid in male and female cynomolgus monkeys trained to discriminate...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Enzyme     Volume:  46     ISSN:  0013-9432     ISO Abbreviation:  Enzyme     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1262265     Medline TA:  Enzyme     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Chicago Medical School, Ill.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Ascorbic Acid / metabolism*
Dehydroascorbic Acid / metabolism*
Free Radicals
Humans
Oxidation-Reduction
Oxidoreductases / metabolism
Grant Support
ID/Acronym/Agency:
EY 07320/EY/NEI NIH HHS; HD 20398/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Free Radicals; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid; EC 1.-/Oxidoreductases; EC 1.8.5.1/glutathione dehydrogenase (ascorbate)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hyperoxia elevates Cu,Zn-superoxide dismutase of endothelial cells as detected by a sensitive ELISA.
Next Document:  A rapid and strong increase of plasminogen activator induced by experimental anaphylaxis in rabbits.