Document Detail

Tissue kallikrein-kinin system in the brain and the regulation of arterial pressure.
MedLine Citation:
PMID:  1334357     Owner:  NLM     Status:  MEDLINE    
The intracerebral administration of kininase inhibitors produced an increase in arterial pressure of the SHR but not in normotensive animals. The SHR were several fold more sensitive to the pressor response elicited by the intracerebral injection of bradykinin, however SHR with low blood pressure showed decreased sensitivity to the bradykinin pressor effect. The results suggest that an endogenous kinin system plays a role in the central regulation of blood pressure of the SHR.
D R Fior; D T Martins; C J Lindsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  38 ( Pt 3)     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1992  
Date Detail:
Created Date:  1993-01-13     Completed Date:  1993-01-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Department of Biophysics, Escola Paulista de Medicina, São Paulo, SP, Brazil.
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MeSH Terms
4-Aminobenzoic Acid / administration & dosage,  analogs & derivatives*,  pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Blood Pressure / drug effects*
Bradykinin / administration & dosage,  pharmacology*
Cerebral Ventricles / drug effects,  physiology*
Dose-Response Relationship, Drug
Enalaprilat / administration & dosage,  pharmacology*
Injections, Intraventricular
Oligopeptides / administration & dosage,  pharmacology*
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Oligopeptides; 150-13-0/4-Aminobenzoic Acid; 58-82-2/Bradykinin; 84680-54-6/Enalaprilat; 90991-75-6/N-(1-carboxy-2-phenylethyl)-alanyl-alanyl-phenylalanine-4-aminobenzoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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