| Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality. | |
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MedLine Citation:
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PMID: 18343723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF). AIMS: We investigated the association of plasma levels of soluble MMP-9 and TIMP-1 with clinical, laboratory and echocardiographic parameters and estimated their prognostic value in the prediction of all-cause death. METHODS: MMP-9, TIMP-1, tumour necrosis factor-alpha, and amino-terminal pro-brain natriuretic peptide were measured in 249 consecutively enrolled CHF patients and 74 healthy individuals. RESULTS: After adjustment for age, sex and creatinine, levels of TIMP-1 (1640 vs. 735 ng/ml, P<0.001) but not MMP-9 were elevated in CHF patients compared to controls. During a median follow-up period of 2.5 years, 66 patients (27%) died. In multivariable Cox regression models TIMP-1 but not MMP-9 emerged as an independent predictor of all-cause death (hazard ratio per tertile, 3.5; 95% confidence interval [CI], 2.2-5.1). In addition to the full set of univariately predictive clinical and serological markers, information on TIMP-1 significantly increased the area under the receiver operating characteristic curve from 0.77 (95% CI, 0.71-0.84) to 0.87 (95% CI, 0.82-0.92). CONCLUSION: In stable CHF patients, TIMP-1 but not MMP-9 is of independent and incremental value regarding the prediction of all-cause death. |
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Authors:
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S Frantz; S Störk; K Michels; M Eigenthaler; G Ertl; J Bauersachs; C E Angermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-17 |
Journal Detail:
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Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-09-22 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 388-95 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Würzburg, Würzburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cardiac Output, Low / blood, diagnosis, mortality Cause of Death Echocardiography Female Heart Failure / blood*, diagnosis, mortality* Humans Male Matrix Metalloproteinase 9 / blood* Middle Aged Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Reference Values Tissue Inhibitor of Metalloproteinase-1 / blood* Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tissue Inhibitor of Metalloproteinase-1; 0/Tumor Necrosis Factor-alpha; EC 3.4.24.35/Matrix Metalloproteinase 9 |
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