| Tissue homing and persistence of defined antigen-specific CD8+ tumor-reactive T-cell clones in long-term melanoma survivors. | |
| | |
MedLine Citation:
|
PMID: 17039243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tumor antigen-specific cytotoxic T cells (CTLs) play a major role in the adaptive immune response to cancers. This CTL response is often insufficient because of functional impairment, tumor escape mechanisms, or inhibitory tumor microenvironment. However, little is known about the fate of given tumor-specific CTL clones in cancer patients. Studies in patients with favorable outcomes may be very informative. In this longitudinal study, we tracked, quantified, and characterized functionally defined antigen-specific T-cell clones ex vivo, in peripheral blood and at tumor sites, in two long-term melanoma survivors. MAGE-A10-specific CD8+ T-cell clones with high avidity to antigenic peptide and tumor lytic capabilities persisted in peripheral blood over more than 10 years, with quantitative variations correlating with the clinical course. These clones were also found in emerging metastases, and, in one patient, circulating clonal T cells displayed a fully differentiated effector phenotype at the time of relapse. Longevity, tumor homing, differentiation phenotype, and quantitative adaptation to the disease phases suggest the contribution of the tracked tumor-reactive clones in the tumor control of these long-term metastatic survivor patients. Focusing research on patients with favorable outcomes may help to identify parameters that are crucial for an efficient antitumor response and to optimize cancer immunotherapy. |
| | |
Authors:
|
Frédérique-Anne Le Gal; Valérie M Widmer; Valérie Dutoit; Verena Rubio-Godoy; Jacques Schrenzel; Paul R Walker; Pedro J Romero; Danila Valmori; Daniel E Speiser; Pierre-Yves Dietrich |
Related Documents
:
|
12808113 - Binding sites for lewis antigens are expressed by human colon cancer cells and negative... 8325703 - Identification of colon-tumor-associated antigens by t-cell lines derived from tumor-in... 18020923 - Inhibition of angiogenesis and invasion in malignant gliomas. |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-12 |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 127 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-14 Completed Date: 2007-03-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 622-9 Citation Subset: IM |
Affiliation:
|
Laboratory of Tumor Immunology, Division of Oncology, Department of Internal Medicine, University Hospital, Geneva, Switzerland. frederique-anne.legal@hcuge.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, Neoplasm
/
immunology CD8-Positive T-Lymphocytes / immunology* Cell Differentiation Disease Progression Flow Cytometry Humans Immunotherapy Leukocytes, Mononuclear / cytology Male Melanoma / blood, immunology* Middle Aged Neoplasm Metastasis Neoplasm Proteins / immunology Phenotype Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Neoplasm; 0/MAGEA10 protein, human; 0/Neoplasm Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients.
Next Document: Epidermolysis bullosa simplex in Scotland caused by a spectrum of keratin mutations.