Document Detail

Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy.
MedLine Citation:
PMID:  19123673     Owner:  NLM     Status:  MEDLINE    
We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (S(t)O(2)) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p<0.001). OHb, S(t)O(2), and THb decrease (p<0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p=0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r(2)=0.95) and Q (r(2)=0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP.
Jangwoen Lee; Jae G Kim; Sari Mahon; Bruce J Tromberg; Kathy L Ryan; Victor A Convertino; Caroline A Rickards; Kathryn Osann; Matthew Brenner
Related Documents :
2877953 - Dihydroergotamine therapy in orthostatic hypotension due to psychotropic drugs.
15806683 - Relationship between stroke volume and sympathetic nerve activity: new insights about a...
20884713 - Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 mont...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  13     ISSN:  1083-3668     ISO Abbreviation:  J Biomed Opt     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-03-19     Revised Date:  2014-09-01    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  064027     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diagnosis, Computer-Assisted / methods*
Hemoglobins / analysis*
Hypovolemia / diagnosis*,  metabolism*
Lower Body Negative Pressure / methods
Oxygen / analysis*
Reproducibility of Results
Sensitivity and Specificity
Spectroscopy, Near-Infrared / methods*
Young Adult
Grant Support
Reg. No./Substance:
0/Hemoglobins; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative depth analysis of optic nerve head using stereo retinal fundus image pair.
Next Document:  In vivo staining of neocortical astrocytes via the cerebral microcirculation using sulforhodamine B.