Document Detail

Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment.
MedLine Citation:
PMID:  3120768     Owner:  NLM     Status:  MEDLINE    
1. Long-term exposure of the fruit bat Rousettus aegyptiacus to nitrous oxide, which inactivates methylcobalamin, leads to neurological impairment and ataxia. 2. In N2O-exposed animals, liver concentrations of total folates and methyl folates decreased to less than one-fifth that of control animals. Pediococcus cerevisiae-active folates were also reduced. 3. In brain, there were no changes in total or methyl folates, but P. cerevisiae-active folates were lower in N2O-exposed animals. 4. Supplementation with methionine retarded the development of neurological impairment and the fall in liver total and methyl folates, but not that in P. cerevisiae-active folates. 5. Supplementation with serine failed to retard the development of neurological impairment or fall in hepatic folates. 6. The present results suggest that the N2O-induced neurological impairment in the bat is not related to depletion of cerebral folates, but do not exclude changes in the subcellular distribution of folates.
J van der Westhuyzen; R E Davis; G C Icke; J Metz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  58     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-23     Completed Date:  1988-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
Department of Haematology, School of Pathology, South African Institute for Medical Research, Johannesburg.
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MeSH Terms
Brain / metabolism
Folic Acid / metabolism*
Liver / metabolism
Methionine / administration & dosage
Nervous System Diseases / chemically induced,  diet therapy,  metabolism*
Nitrous Oxide
Serine / administration & dosage
Vitamin B 12 Deficiency / chemically induced,  metabolism*
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 56-45-1/Serine; 59-30-3/Folic Acid; 63-68-3/Methionine

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