Document Detail


Tissue factor and tissue factor pathway inhibitor in hemodialysis patients.
MedLine Citation:
PMID:  9894744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue factor and tissue factor pathway inhibitor are important in extrinsic coagulation. We investigated their clinical significance in hemodialysis patients. We took blood samples, prior to initiation of routine hemodialysis, from 73 patients on hemodialysis (35 men and 38 women aged 56.1+/-11.7 years on dialysis for 82.1+/-61.0 months), and determined tissue factor and tissue factor pathway inhibitor levels by ELISA. In the patients the tissue factor level was 704.5+/-141.6 pg/ml and the tissue factor pathway inhibitor level was 44.5+/-23.3 ng/ml; both values were significantly higher than in normal controls (192.7+/-36.6 pg/ml and 18.6+/-5.7 ng/ml, respectively). In patients with shunt obstruction, tissue factor pathway inhibitor levels were significantly higher than in those without it. Therefore, the tissue factor pathway inhibitor level may be a marker of shunt obstruction.
Authors:
N Yorioka; Y Taniguchi; K Yamashita; C Ueda; C Nakamura; S Harada; M Yamakido
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  21     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-03-24     Completed Date:  1999-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  699-701     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Kidney Failure, Chronic / blood,  complications,  therapy
Lipoproteins / blood*
Male
Middle Aged
Renal Dialysis*
Thromboplastin / analysis*
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/lipoprotein-associated coagulation inhibitor; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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