Document Detail

Tissue factor/tissue factor pathway inhibitor system and long-term prognosis after acute myocardial infarction.
MedLine Citation:
PMID:  11334654     Owner:  NLM     Status:  MEDLINE    
METHODS: We studied 55 consecutive patients with the following criteria for inclusion: (1) first myocardial infarct; (2) aged < 70 years; (3) non-complicated infarct; (4) low risk effort-test. Blood samples were taken 60-80 days after infarction. Tissue factor, total and free-TFPI were measured. A 4-year follow-up was carried out. Death, unstable angina and new myocardial infarction were considered as poor prognosis.
RESULTS: There were no statistical differences in tissue factor/TFPI levels between patients and controls. Total-TFPI showed statistical correlation with total cholesterol (r = 0.59), triglycerides (r = 0.34), LDL-cholesterol (r = 40) and Lipoprotein(a) (r = 0.48). Patients with high levels of cholesterol, LDL-cholesterol and triglycerides showed elevated levels of total-TFPI with no differences in free-TFPI. During follow-up, 8 patients showed poor prognosis. There were no statistical associations between tissue factor/TFPI levels and prognosis.
CONCLUSIONS: After acute myocardial infarction, we did not find any differences in the tissue factor/TFPI system between controls and patients. The tissue factor/TFPI system showed little value as a prognostic factor.
V Roldán; F Marín; P Fernández; J Luján; J G Martínez; J Pineda; P Marco; F Sogorb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  78     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-03     Completed Date:  2001-07-19     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Biological Markers
Case-Control Studies
Coronary Disease / epidemiology,  mortality
Follow-Up Studies
Lipoproteins / blood*
Middle Aged
Myocardial Infarction / blood,  diagnosis*,  epidemiology
Statistics, Nonparametric
Thromboplastin / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Lipoproteins; 0/lipoprotein-associated coagulation inhibitor; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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