Document Detail


Tissue factor and its natural inhibitor in pre-eclampsia and SGA.
MedLine Citation:
PMID:  19065458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Tissue factor (TF), the major activator of the extrinsic pathway of coagulation, is abundant in the placenta and decidua. The aim of this study was to determine the maternal plasma concentrations of TF and its primary inhibitor, tissue factor pathway inhibitor (TFPI), in women who delivered small for gestational age (SGA) neonates, and in pre-eclampsia.
STUDY DESIGN: A cross-sectional study included the following groups: 1) women with normal pregnancies (n = 86); 2) patients who delivered SGA neonates (n = 61) and 3) women with pre-eclampsia (n = 133). Maternal plasma concentrations of TF and TFPI were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis.
RESULTS: 1) Women with pre-eclampsia had a significantly higher median plasma concentration of TF than patients with a normal pregnancy (median: 1187 pg/mL; range: 69-11675 vs. median: 291.5 pg/mL; range: 6.3-2662.2; p < 0.0001, respectively); 2) Similarly, TFPI concentrations were higher in pre-eclampsia than in normal pregnancy (median: 87.5 ng/mL; range 25.4-165.1 vs. median: 66.1 ng/mL; range: 14.3-86.5; p < 0.0001, respectively); 3) Surprisingly, mothers with SGA neonates had a lower median maternal plasma concentration of TF (median: 112.2 pg/mL; range: 25.6-1225.3) than women with a normal pregnancy (p < 0.0001).
CONCLUSION: 1) Maternal plasma concentrations of TF in patients with pre-eclampsia, but not in those who delivered an SGA neonate, were higher than in women with normal pregnancies; 2) Although the role of immunoreactive plasma TF in coagulation remains controversial, our observations suggest that changes are present in the context of complications of pregnancy.
Authors:
Offer Erez; Roberto Romero; Debra Hoppensteadt; Nandor Gabor Than; Jawed Fareed; Shali Mazaki-Tovi; Jimmy Espinoza; Tinnakorn Chaiworapongsa; Sung-Su Kim; Bo Hyun Yoon; Sonia S Hassan; Francesca Gotsch; Lara Friel; Edi Vaisbuch; Juan Pedro Kusanovic
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  21     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-03-17     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-69     Citation Subset:  IM    
Affiliation:
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Female
Fetal Growth Retardation / blood*,  pathology
Humans
Infant, Newborn
Infant, Small for Gestational Age
Lipoproteins / blood*
Placenta / pathology
Pre-Eclampsia / blood*,  pathology
Pregnancy
Thromboplastin / metabolism*
Young Adult
Grant Support
ID/Acronym/Agency:
ZIA HD002400-19/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/lipoprotein-associated coagulation inhibitor; 9035-58-9/Thromboplastin
Comments/Corrections

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