Document Detail

Tissue factor in human coronary atherosclerotic plaques.
MedLine Citation:
PMID:  10675726     Owner:  NLM     Status:  MEDLINE    
The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture.
D Ardissino; P A Merlini; R Arlens; R Coppola; E Bramucci; S Lucreziotti; A Repetto; R Fetiveau; P M Mannucci
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  291     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Division of Cardiology, I.R.C.C.S. Policlinico San Matteo and University of Pavia, Piazza Golgi 1, 27100, Pavia, Italy.
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MeSH Terms
Coronary Artery Disease / metabolism*
Thromboplastin / metabolism*
Reg. No./Substance:

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