Document Detail


Tissue factor-dependent thrombin generation across pregnancy.
MedLine Citation:
PMID:  22840726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Normal pregnancy results in a prothrombotic state. Studies that have investigated the capacity of pregnant women to generate thrombin are limited. Our aim was to evaluate thrombin generation longitudinally from the preconception period, through pregnancy, and after pregnancy.
STUDY DESIGN: We evaluated young, healthy nulligravid women (n = 20) at 4 time points and compared the data with 10 control women at 2 time points. Coagulation was initiated with tissue factor in contact pathway inhibited plasma, and thrombin generation was determined in the presence of a fluorogenic substrate.
RESULTS: The maximum level and rate of thrombin generation increased during pregnancy; the highest level and rate occurred in late pregnancy compared with prepregnancy (P < .001). Subsequently, thrombin generation decreased in the postpregnancy samples that included maximum level, rate, and area under the curve (P < .001).
CONCLUSION: Our data provide evidence for an increase in tissue factor-dependent thrombin generation with pregnancy progression, followed by a return to prepregnancy thrombin levels.
Authors:
Kelley C McLean; Ira M Bernstein; Kathleen E Brummel-Ziedins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-11
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-10-24     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012. Published by Mosby, Inc.
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Sciences, Fletcher Allen Health Care/University of Vermont, Burlington, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Hemoglobins / analysis
Humans
Platelet Count
Postpartum Period / blood
Pregnancy / blood*
Thrombin / analysis*,  biosynthesis*
Grant Support
ID/Acronym/Agency:
HL 71944/HL/NHLBI NIH HHS; HL46703/HL/NHLBI NIH HHS; P01 HL046703/HL/NHLBI NIH HHS; R01 HL071944/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Hemoglobins; 0/fibrin fragment D; 9001-32-5/Fibrinogen; EC 3.4.21.5/Thrombin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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