| Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium. | |
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MedLine Citation:
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PMID: 12270558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Placental abruption is mainly due to the rupture of the uterine spiral arteries, but adjacent tissues are also damaged and substances derived from disintegrated placenta and myometrium probably cause coagulation disturbances, such as hypofibrinogenemia and disseminated intravascular coagulation (DIC). AIM: To measure whether placenta and myometrium are significant sources of tissue factor (TF) and tissue factor pathway inhibitor (TFPI), the components of key role in the initiation of coagulation. MATERIALS AND METHODS: Strips of placenta and myometrium were obtained from 48 women delivered by cesarean section at term. TF and TFPI concentrations were measured by immunoenzymatic method (ELISA) in tissue homogenates. MAIN RESULTS: Concentration of TF in placenta and myometrium was 31 (25-37) and 7.4 (4.9-11.4) ng/mg of total protein, respectively. In the plasma of the same women, it was 0.004ng/mg of total protein. TFPI concentration was 13 (10-17) ng/mg of total protein in placenta, 4.5 (3.1-7.3) ng/mg in myometrium, and 0.70 (0.50-0.80) ng/mg in blood plasma protein. CONCLUSION: The levels of TF in placenta and myometrium, over TF in blood plasma may be clinically significant in obstetrics, for instance, in the etiology of DIC in placental abruption. The concentration of TFPI-natural inhibitor of TF-seems to be too low to prevent initiation of coagulation. |
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Authors:
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Jarosław Kuczyński; Waldemar Uszyński; Ewa Zekanowska; Tomasz Soszka; Mieczysław Uszyński |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 105 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-24 Completed Date: 2003-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 15-9 Citation Subset: IM |
Affiliation:
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Regional Hospital, Suwalki, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cesarean Section Female Humans Lipoproteins / analysis*, blood Myometrium / chemistry* Placenta / chemistry* Pregnancy Thromboplastin / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/lipoprotein-associated coagulation inhibitor; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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