Document Detail


Tissue extravasation of albumin from intraabdominal trauma in rats.
MedLine Citation:
PMID:  2038934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraabdominal surgery tends to lower circulating plasma volume by mechanisms unrelated to bleeding and evaporation. In chloralose-anesthetized rats, the tissue clearance of radiolabelled albumin was determined by a double isotope method. Animals were subjected to a standardized abdominal trauma, eliciting minimal bleeding and evaporation, and others served as controls. The trauma significantly increased tissue albumin extravasation in abdominal skin, abdominal wall, pancreas, small intestine, colon, mesentery and diaphragm. Considering the mass of the respective tissues, a substantial portion of the albumin extravasation took place in the abdominal wall. No increased albumin clearance was found in extra-abdominal tissues. It is suggested that abdominal surgery decreases plasma volume by extravasation in the operation field.
Authors:
G Akerström; B Lisander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  35     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-03     Completed Date:  1991-07-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care, Sahlgren's Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Injuries / metabolism*,  radionuclide imaging
Animals
Male
Rats
Rats, Inbred Strains
Serum Albumin / metabolism*
Serum Albumin, Radio-Iodinated / diagnostic use,  pharmacokinetics
Tissue Distribution
Chemical
Reg. No./Substance:
0/Serum Albumin; 0/Serum Albumin, Radio-Iodinated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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