| Tissue extract from dopamine-depleted striatum enhances differentiation of cultured striatal type-1 astrocytes. | |
| | |
MedLine Citation:
|
PMID: 8852591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of tissue extract from dopamine (DA)-depleted striatum (lesion extract, L-ext) on morphological and electrophysiological natures of cultured striatal astrocytes were investigated. L-ext treatment suppressed the proliferation of type-1 astrocytes. They became fibrous in a concentration-dependent manner. These changes were not observed in type-2 astrocytes. By whole cell patch-clamp recording, two kinetically and pharmacologically distinct voltage-activated potassium currents, A current and delayed rectifier, were identified. L-ext treatment enhanced both currents in type-1 astrocytes, but only A current in type-2. Data suggest that in tissue extract from DA-depleted striatum, there are increased trophic activities that promote the differentiation of type-1 astrocytes. |
| | |
Authors:
|
Y Shimano; A Fukuda; I Fujimoto; H Hida; K Nakajima; A Okabe; H Nishino |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neuroscience letters Volume: 205 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1996 Mar |
Date Detail:
|
Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 193-6 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Nagoya City University Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Astrocytes / physiology*, ultrastructure Cell Differentiation / physiology Cell Division / physiology Cell Extracts Cells, Cultured / physiology, ultrastructure Dopamine / deficiency* Immunohistochemistry Neostriatum / cytology*, physiology Patch-Clamp Techniques Potassium Channels / metabolism Rats Rats, Wistar Sodium Channels / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cell Extracts; 0/Potassium Channels; 0/Sodium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal e...
Next Document: Cultured rat neuronal and glial cells entrapped within hydrogel polymer matrices: a potential tool f...