| Tissue engineering and the use of stem/progenitor cells for airway epithelium repair. | |
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MedLine Citation:
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PMID: 20571996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stem/progenitor cells can be used to repair defects in the airway wall, resulting from e.g., tumors, trauma, tissue reactions following long-time intubations, or diseases that are associated with epithelial damage. Several potential sources of cells for airway epithelium have been identified. These can be divided into two groups. The first group consists of endogenous progenitor cells present in the respiratory tract. This group can be subdivided according to location into (a) a ductal cell type in the submucosal glands of the proximal trachea, (b) basal cells in the intercartilaginous zones of the lower trachea and bronchi, (c) variant Clara cells (Clara v-cells) in the bronchioles and (d) at the junctions between the bronchioles and the alveolar ducts, and (e) alveolar type II cells. This classification of progenitor cell niches is, however, controversial. The second group consists of exogenous stem cells derived from other tissues in the body. This second group can be subdivided into: (a) embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, or amniotic fluid stem cells, (b) side-population cells from bone marrow or epithelial stem cells present in bone marrow or circulation and (c) fat-derived mesenchymal cells. Airway epithelial cells can be co-cultured in a system that includes a basal lamina equivalent, extracellular factors from mesenchymal fibroblasts, and in an air-liquid interface system. Recently, spheroid-based culture systems have been developed. Several clinical applications have been suggested: cystic fibrosis, acute respiratory distress syndrome, chronic obstructive lung disease, pulmonary fibrosis, pulmonary edema, and pulmonary hypertension. Clinical applications so far are few, but include subglottic stenosis, tracheomalacia, bronchiomalacia, and emphysema. |
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Authors:
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Godfried M Roomans |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-23 |
Journal Detail:
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Title: European cells & materials Volume: 19 ISSN: 1473-2262 ISO Abbreviation: Eur Cell Mater Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973416 Medline TA: Eur Cell Mater Country: Scotland |
Other Details:
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Languages: eng Pagination: 284-99 Citation Subset: IM |
Affiliation:
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School of Health and Medical Sciences, Orebro University, Orebro University Hospital, SE-70185 Orebro, Sweden. godfried.roomans@oru.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Epithelial Cells
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cytology*,
physiology Humans Regeneration* Regenerative Medicine / methods Respiratory System / cytology* Stem Cells / cytology, physiology* Tissue Engineering / methods* Wound Healing |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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