| Tissue engineering and regenerative medicine: role of toxicologic pathologists for an emerging medical technology. | |
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MedLine Citation:
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PMID: 18337226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue Engineering Regenerative Medical (TERM) products are a new technology currently in human clinical testing for a variety of unmet medical needs involving tissue and organ dysfunction and failure. Safety evaluation of TERM products overlaps 3 established product paradigms: pharmaceuticals (biologically active substances), transplantation (cells or tissue), and devices (biomaterials). As TERM products recapitulate organ or tissue structure and function with unique biological activity and characteristics, they require new preclinical paradigms to bring TERM products through to clinical trials. Establishing TERM-product safety programs requires broad-based knowledge of tissue and organ homeostasis, regenerative biology, and translational medicine to design new preclinical paradigms. Therefore, toxicologic pathologists have a compelling scientific role in evaluating TERM products, characterizing tissue responses, and helping distinguish optimal (regeneration) from deficient or incomplete outcomes indicative of substandard functionality (repair). As new-tissue engineering and regenerative medical technologies develop for tissue and organ regeneration, the toxicologic pathologist will be asked to develop novel testing, reevaluate established toxicologic diagnostic criteria, and reinterpret tissue responses that may extend beyond current standards. |
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Authors:
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Manuel J Jayo; David D Watson; Belinda J Wagner; Timothy A Bertram |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicologic pathology Volume: 36 ISSN: 1533-1601 ISO Abbreviation: Toxicol Pathol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-03-13 Completed Date: 2008-04-10 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 92-6 Citation Subset: IM |
Affiliation:
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Tengion, Inc., Winston-Salem, North Carolina 27103, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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adverse effects* Humans Pathology / methods*, trends Regenerative Medicine / methods*, trends Risk Assessment Tissue Engineering / methods*, trends Toxicity Tests / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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