| Tissue engineering of heart valves: advances and current challenges. | |
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MedLine Citation:
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PMID: 19419284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is estimated that the number of patients requiring heart valve replacement will triple over the next five decades. None of the current replacement valves can fully restore native valve function because they lack growth and remodeling capabilities. Heart valve tissue engineering is a promising technology to overcome these limitations. Various approaches are being employed, either aimed at development of the valve substitute in vitro or at the use of the regenerative potential of the body (in situ) for the tissue culture phase. This review provides an overview of the progress within both the in vitro and in situ tissue engineering approaches for trileaflet heart valve tissue engineering. Current challenges with these approaches are discussed, focusing in particular on the use of synthetic scaffold materials. |
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Authors:
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Anita Mol; Anthal I P M Smits; Carlijn V C Bouten; Frank P T Baaijens |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of medical devices Volume: 6 ISSN: 1745-2422 ISO Abbreviation: - Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-07 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230445 Medline TA: Expert Rev Med Devices Country: England |
Other Details:
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Languages: eng Pagination: 259-75 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands. a.mol@tue.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bioprosthesis* Heart Valve Diseases / therapy* Heart Valve Prosthesis* Heart Valve Prosthesis Implantation / methods, trends Humans Tissue Engineering / methods*, trends Tricuspid Valve* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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