Document Detail


Tissue engineering of cardiovascular structures.
MedLine Citation:
PMID:  9429823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital and acquired diseases of the heart valves and great arteries are leading causes of morbidity and mortality. Current prosthetic or bioprosthetic replacement devices are imperfect and subject patients to one or more ongoing risks including thrombosis, limited durability, increased susceptibility to infection, and need for reoperations due to lack of growth. Tissue engineering (TE) is a new discipline that offers the potential to create replacement structures from autologous cells and biodegradable polymers. Because TE constructs contain living cells, they may have the potential for growth and self-repair and remodeling. Cardiac valve leaflets and large conduit arteries have been made with the TE approach. These TE structures have functioned in the pulmonary circulation of growing lambs for up to 4 months and have demonstrated 1) structural organization to resemble normal valve and artery, 2) satisfactory physiologic function, 3) lack of thrombus formation, and 4) growth.
Authors:
J E Mayer; T Shin'oka; D Shum-Tim
Related Documents :
6230973 - Modified techniques for improving the continent ileostomy.
20576933 - Elastin haploinsufficiency results in progressive aortic valve malformation and latent ...
23332823 - Biomechanical properties and histological structure of sinus of valsalva aneurysms in r...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  12     ISSN:  0268-4705     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2006-05-04    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-32     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, Children's Hospital, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Biomedical Engineering / methods*
Cardiac Surgical Procedures*
Cardiovascular Diseases / surgery*
Cardiovascular System / anatomy & histology
Humans
Chemical
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic manipulation of vein grafts.
Next Document:  Ventricular remodeling in coronary artery disease.