| Tissue engineering of blood vessel. | |
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MedLine Citation:
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PMID: 17979876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular grafts are in large demand for coronary and peripheral bypass surgeries. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter or in the areas of low blood flow, mainly due to the early formation of thrombosis. Moreover, the commonly used materials lack growth potential, and long-term results have revealed several material-related failures, such as stenosis, thromboembolization, calcium deposition and infection. Tissue engineering has become a promising approach for generating a bio-compatible vessel graft with growth potential. Since the first success of constructing blood vessels with collagen and cultured vascular cells by Weinberg and Bell, there has been considerable progress in the area of vessel engineering. To date, tissue- engineered blood vessels (TEBVs) could be successfully constructed in vitro, and be used to repair the vascular defects in animal models. This review describes the major progress in the field, including the seeding cell sources, the biodegradable scaffolds, the construction technologies, as well as the encouraging achievements in clinical applications. The remaining challenges are also discussed. |
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Authors:
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Wen Jie Zhang; Wei Liu; Lei Cui; Yilin Cao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cellular and molecular medicine Volume: 11 ISSN: 1582-1838 ISO Abbreviation: J. Cell. Mol. Med. Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2008-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101083777 Medline TA: J Cell Mol Med Country: Romania |
Other Details:
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Languages: eng Pagination: 945-57 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, National Tissue Engineering Center of China, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants Animals Biocompatible Materials / metabolism Blood Vessels / cytology, metabolism* Humans Tissue Engineering / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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