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Tissue engineering approaches to degenerative disc disease - a meta-analysis of controlled animal trials.
MedLine Citation:
PMID:  22789805     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The objectives of this systematic review were to assess cell/biomaterial treatments of degenerative disc disease in controlled animal trails. The primary endpoints were restoration of disc height and T2-signal intensity. METHOD: PubMed, CINAHL, EMBASE, CENTRAL, and CDSR were searched for studies reporting on the use of tissue engineering treatments (cells/biomaterials/cells and biomaterials) for degenerative disc disease treatments in a controlled trial. Publication bias was assessed graphically using funnel plots and Egger's regression. Data were grouped by follow-up duration - early (<4 weeks), intermediate (4-12 weeks) and late (> 12 weeks), and weighted mean differences (WMD) were calculated using DerSimonian-Laird Random Effect models RESULTS: 13 papers, published between 2004 and 2011, were included in this study. In comparison with the injured disc, all three treatments showed a positive effect in disc height, but one of the treatments restored disc height compared to the healthy disc. Overall, there seemed to be a better effect on disc height restoration for the treatment with cells and biomaterials. None of the treatments could achieve the same T2 signal intensity as the healthy disc, and compared to the injured disc, only the treatment with cells and biomaterials showed constantly better results. CONCLUSION: Treatment of an injured/degenerating disc with cells, cells plus biomaterial or biomaterial alone has a potential for at least a partial regeneration of the disc. However, so far, none of the treatments is able to effectively restore the properties of a healthy disc.
Arne Mehrkens; Andreas M Müller; Victor Valderrabano; Stefan Schären; Patrick Vavken
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-9
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  -     ISSN:  1522-9653     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada; Orthopaedic Department, University Hospital of Basel, University of Basel, Switzerland.
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