| Tissue-engineered heart valves. | |
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MedLine Citation:
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PMID: 20131932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction, thrombosis and degeneration, and thus they have a high rate of reoperation. Biological prostheses of autologous origin, such as pulmonary autografts, often burden the patient with a complicated surgery and the risk of reoperation. Therefore, efforts are being made to prepare bioartificial heart valves with an autologous biological component by methods of tissue engineering. They should be biocompatible, durable, endowed with appropriate mechanical properties and able to grow with a child. For this purpose, scaffolds composed of synthetic materials, such as poly(lactic acid), poly(caprolactone), poly(4-hydroxybutyrate), hydrogels or natural polymers, e.g. collagen, elastin, fibrin or hyaluronic acid, have been seeded with autologous differentiated, progenitor or stem cells. Promising results have been obtained with nanostructured scaffolds, and also with cultivation in special dynamic bioreactors prior to implantation of the bioartificial grafts into an animal organism. |
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Authors:
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E Filov?; F Straka; T Mirejovsk?; J Mas?n; L Bac?kov? |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 58 Suppl 2 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2009 |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: S141-58 Citation Subset: IM |
Affiliation:
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Center for Cardiovascular Research, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials Bioprosthesis* Heart Valve Prosthesis* Heart Valve Prosthesis Implantation / adverse effects, instrumentation* Humans Prosthesis Design Tissue Culture Techniques Tissue Engineering* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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