Document Detail

Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix.
MedLine Citation:
PMID:  15568538     Owner:  NLM     Status:  MEDLINE    
We have evaluated in vivo a novel, polymer-based, matrix for tissue engineering of bone. A segmental defect of 15 mm was created in the ulna of New Zealand white rabbits to determine the regenerative properties of a porous polylactide-co-glycolide matrix alone and in combination with autogenous marrow and/or the osteoinductive protein, BMP-7. In this study four implant groups were used: 1) matrix alone; 2) matrix with autogenous marrow; 3) matrix with 20 microg of BMP-7; and 4) matrix with 20 microg of BMP-7 and autogenous marrow. The results showed that the degree of bone formation was dependent on the properties of the graft material. The osteoconductive sintered matrix structure showed significant formation of bone at the implant-bone interface. The addition of autogenous marrow increased the penetration of new bone further into the central area of the matrix and also increased the degree of revascularisation. The osteoinductive growth factor BMP-7 induced penetration of new bone throughout the entire structure of the implant. The most effective treatment was with the combination of marrow cells and osteoinductive BMP-7.
M Borden; M Attawia; Y Khan; S F El-Amin; C T Laurencin
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  86     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-30     Completed Date:  2004-12-13     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  1200-8     Citation Subset:  AIM; IM    
University of Virginia, Charlottesville 22903, USA.
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MeSH Terms
Bone Matrix / growth & development,  radiography
Osteogenesis / physiology*
Photomicrography / methods
Tissue Engineering*
Wound Healing
Reg. No./Substance:

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