| Tissue-engineered blood vessels: alternative to autologous grafts? | |
| | |
MedLine Citation:
|
PMID: 15705929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although vascular bypass grafting remains the mainstay for revascularization for ischemic heart disease and peripheral vascular disease, many patients do not have healthy vessels suitable for harvest. Thus, prosthetic grafts made of synthetic polymers were developed, but their use is limited to high-flow/low-resistance conditions because of poor elasticity, low compliance, and thrombogenicity of their synthetic surfaces. To fill this need, several laboratories have produced in vivo or in vitro tissue-engineered blood vessels using molds or prosthetic or biodegradable scaffolds, but each artificial graft has significant problems. Recently, conduits have been grown in the peritoneal cavity of the same animals in which they will be grafted, ensuring no rejection, in the short time of 2 to 3 weeks. Remodeling occurs after grafting such that the tissue is almost indistinguishable from native vessels. This conduit is derived from cells of bone marrow origin, opening new possibilities in vascular modeling and remodeling. |
| | |
Authors:
|
Michel R Hoenig; Gordon R Campbell; Barbara E Rolfe; Julie H Campbell |
Related Documents
:
|
7301069 - Delayed thrombosis of synthetic microvascular bypass grafts. 9788139 - Visualization of flow patterns from stents and stent-grafts in an in vitro flow-model. 2935539 - Reliability of intraoperative flow measurements to determine early graft patency with s... 7041249 - Blood flow and scanning electron microscope study on venous microvascular anastomoses w... 10502059 - Efficacy of subconjunctival cyclosporin-containing microspheres on keratoplasty rejecti... 10452239 - Distribution and localization of cells and collagens in the proliferated intima of arte... 1214129 - An electrophysiological analysis of extra-axonal sodium and potassium concentrations in... 15332619 - Detection of micro- and nano-sized biocompatible particles in the blood. 7624939 - Amlodipine improves hepatic hemodynamic and metabolic function in the isolated perfused... |
Publication Detail:
|
Type: Journal Article; Review Date: 2005-02-10 |
Journal Detail:
|
Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 25 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-30 Completed Date: 2005-12-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 1128-34 Citation Subset: IM |
Affiliation:
|
Centre for Research in Vascular Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Vessel Prosthesis* Blood Vessels / transplantation* Humans Myocardial Ischemia / surgery* Peripheral Vascular Diseases / surgery* Tissue Engineering* Transplantation, Autologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of P-selectin on phosphatidylserine exposure and surface-dependent thrombin generation on mon...
Next Document: Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting...