| Tissue doppler imaging and NT-proBNP levels show the early impairment of ventricular function in patients with beta-thalassaemia major. | |
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MedLine Citation:
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PMID: 17608095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beta-thalassaemia major is a chronic haemolytic anaemia, and congestive heart failure (CHF) is the most common cause of death in this disease. N terminal pro B type natriuretic peptide (NT-proBNP) increases with the severity of CHF and predicts the prognosis. The aim of this study was to investigate the relation between left ventricular systolic and diastolic function determined by standard pulsed wave Doppler (PWD), tissue Doppler imaging (TDI) and NT-proBNP in patients with beta-thalassaemia major. Thirty-four patients with beta-thalassaemia major and 34 healthy individuals were included in the study. Blood samples were taken for NT-proBNP. All patients and controls underwent echocardiographic examination. All cardiac chambers were significantly increased in the patient group. Left and right ventricular (LV, RV) ejection fractions and all diastolic parameters were normal in the patients and controls. Tissue Doppler imaging (TDI) showed a significant decrease in LV and RV Sm velocities in patients compared to the controls. NT-proBNP levels were also significantly higher in the patient group. There was a negative correlation between serum NT-proBNP levels and LV Sm and RV Sm velocities in patients (r = -0.426, P = 0.006 and r = -0.409, P = 0.009, respectively). Linear regression analysis showed that LV Sm and RV Sm were independent predictors for NT-proBNP. Our findings suggest that although iron overload in patients with beta-thalassaemia major impairs the systolic and diastolic functions of both ventricles, it impairs the systolic function earlier than diastolic function. Tissue Doppler imaging is an easy and reliable method in the early determination of ventricular dysfunction in these patients. |
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Authors:
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Onur Akpinar; Esmeray Acartürk; Mehmet Kanadaşi; Cağatay Unsal; Fikri Başlamişli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 62 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-04 Completed Date: 2007-07-31 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 225-31 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Cukurova University, School of Medicine, Adana, Turkey. onur_akpinar@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Echocardiography, Doppler* Female Humans Linear Models Male Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Predictive Value of Tests Prognosis Ventricular Dysfunction, Left / blood*, ultrasonography* beta-Thalassemia / blood*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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