Document Detail


Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) from the Dutch Wadden Sea.
MedLine Citation:
PMID:  16201619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfluorinated acids (PFAs) are today widely distributed in the environment, even in remote arctic areas. Recently, perfluorooctane sulfonate (PFOS) has been identified in marine mammals all over the world, but information on the compound-specific tissue distribution remains scarce. Furthermore, although longer perfluorinated carboxylic acids (PFCAs) are used in industry and were shown to cause severe toxic effects, still little is known on potential sources or their widespread distribution. In this study, we report for the first time on levels of longer chain PFCAs, together with some short chain PFAs, perfluorobutane sulfonate (PFBS) and perfluorobutanoate (PFBA), in liver, kidney, blubber, muscle, and spleen tissues of harbor seals (Phoca vitulina) from the Dutch Wadden Sea. PFOS was the predominant compound in all seal samples measured (ranging from 89 to 2724 ng/g wet weight); however, large variations between tissues were monitored. Although these are preliminary results, it is, to our knowledge, the first time that PFBS could be found at detectable concentrations (2.3 +/- 0.7 ng/g w wt) in environmental samples. PFBS was only detected in spleen tissue. PFCA levels were much lower than PFOS concentrations. The dominant PFCA in all tissues was PFNA (perfluorononanoic acid), and concentrations generally decreased in tissues for all other PFCA homologues with increasing chain length. No clear relationship between PFOS levels in liver and kidney was observed. Furthermore, hepatic PFDA (perfluorodecanoic acid) levels increased with increasing body length, but in kidney tissue, PFDA levels showed an inverse relationship with increasing body length. These data suggest large differences in tissue distribution and accumulation patterns of perfluorinated compounds in marine organisms.
Authors:
Kristin Inneke Van de Vijver; Philippe Hoff; Krishna Das; Sophie Brasseur; Walter Van Dongen; Eddy Esmans; Peter Reijnders; Ronny Blust; Wim De Coen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  39     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2005-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6978-84     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerpen, Belgium. inneke.vandevijver@ua.ac.be
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MeSH Terms
Descriptor/Qualifier:
Alkanesulfonic Acids / analysis*
Animals
Body Size
Carboxylic Acids / analysis
Chromatography, Liquid
Distemper / mortality
Distemper Virus, Phocine / metabolism
Environmental Monitoring
Environmental Pollutants / analysis*
Female
Fluorocarbons / analysis*
Kidney / pathology
Male
Mass Spectrometry
Octanoic Acids / analysis*
Pinnipedia
Sex Factors
Sulfonic Acids / analysis
Time Factors
Tissue Distribution
Water Pollutants, Chemical
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Carboxylic Acids; 0/Environmental Pollutants; 0/Fluorocarbons; 0/Octanoic Acids; 0/Sulfonic Acids; 0/Water Pollutants, Chemical; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid; 355-25-9/perfluorobutane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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