Document Detail

Tissue distribution of penicillin during constant rate infusion in rats at 71 ATA.
MedLine Citation:
PMID:  4035818     Owner:  NLM     Status:  MEDLINE    
Benzyl[14C]penicillin was infused at a constant rate of 100 mg X kg-1 X h-1 for 90 min in rats at 1 ATA air for the control group (n = 10) and at 71 ATA He-O2 for the pressure group (n = 11). The radioactivity was measured in the arterial blood, brain, liver, kidney, muscle, and fat. The mean brain penicillin concentration after 90 min infusion was approximately 20% increased at 71 ATA (P less than 0.05), but the brain: blood concentration ratio was not significantly affected. The mean blood, liver, and muscle penicillin content was slightly higher and the mean kidney content was slightly lower at pressure, but no statistically significant changes were observed.
L Aanderud; O M Bakke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Undersea biomedical research     Volume:  12     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-10-03     Completed Date:  1985-10-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM; S    
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MeSH Terms
Adipose Tissue / metabolism
Brain / metabolism
Hydrostatic Pressure*
Kidney / metabolism
Liver / metabolism
Muscles / metabolism
Penicillin G / blood,  metabolism*
Rats, Inbred Strains
Time Factors
Tissue Distribution
Reg. No./Substance:
61-33-6/Penicillin G

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