Document Detail


Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say).
MedLine Citation:
PMID:  17365616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microcystin (MC) concentrations were measured in the alimentary tract, digestive gland, and remaining visceral mass of adult pulmonate snails (Lymnaea stagnalis) exposed to cyanobacteria known to contain MC. The highest proportion of total body MC content was measured within the alimentary tract (83%), though an appreciable proportion (17%) was also found within the digestive gland tissue. This provides conclusive evidence for the limited digestion of toxic cyanobacteria and subsequent uptake and accumulation of MC by the digestive gland of L. stagnalis. Additionally, pure microcystin-LR was orally administered to adult L. stagnalis to investigate the potential for toxic effects. Exposure to microcystin-LR induced histopathological alterations of the digestive glands consistent with those reported elsewhere for mammals and fish, indicating a common mode of toxicity to both vertebrates and invertebrates.
Authors:
Ronald W Zurawell; Jeff I Goldberg; Charles F B Holmes; Ellie E Prepas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  70     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  620-6     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. ron.zurawell@gov.ab.ca
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bacterial Toxins / pharmacokinetics*,  toxicity
Cyanobacteria / growth & development,  metabolism
Enzyme Inhibitors / pharmacokinetics*,  toxicity
Eutrophication
Fresh Water / microbiology
Gastrointestinal Tract / drug effects,  metabolism*
Lymnaea / metabolism*
Microcystins / pharmacokinetics*,  toxicity
Tissue Distribution
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Enzyme Inhibitors; 0/Microcystins; 77238-39-2/microcystin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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