| Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say). | |
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MedLine Citation:
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PMID: 17365616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microcystin (MC) concentrations were measured in the alimentary tract, digestive gland, and remaining visceral mass of adult pulmonate snails (Lymnaea stagnalis) exposed to cyanobacteria known to contain MC. The highest proportion of total body MC content was measured within the alimentary tract (83%), though an appreciable proportion (17%) was also found within the digestive gland tissue. This provides conclusive evidence for the limited digestion of toxic cyanobacteria and subsequent uptake and accumulation of MC by the digestive gland of L. stagnalis. Additionally, pure microcystin-LR was orally administered to adult L. stagnalis to investigate the potential for toxic effects. Exposure to microcystin-LR induced histopathological alterations of the digestive glands consistent with those reported elsewhere for mammals and fish, indicating a common mode of toxicity to both vertebrates and invertebrates. |
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Authors:
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Ronald W Zurawell; Jeff I Goldberg; Charles F B Holmes; Ellie E Prepas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 70 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-16 Completed Date: 2007-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: England |
Other Details:
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Languages: eng Pagination: 620-6 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. ron.zurawell@gov.ab.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bacterial Toxins / pharmacokinetics*, toxicity Cyanobacteria / growth & development, metabolism Enzyme Inhibitors / pharmacokinetics*, toxicity Eutrophication Fresh Water / microbiology Gastrointestinal Tract / drug effects, metabolism* Lymnaea / metabolism* Microcystins / pharmacokinetics*, toxicity Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Enzyme Inhibitors; 0/Microcystins; 77238-39-2/microcystin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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