Document Detail

Tissue distribution of hyalinazing vasculopathy lesions in peritoneal dialysis patients: an autopsy study.
MedLine Citation:
PMID:  18467038     Owner:  NLM     Status:  MEDLINE    
Uremia is considered capable of inducing structural anomalies of the peritoneum, including hyalinizing vasculopathy (HV). To further elucidate the contribution of uremia to the severity of HV, we performed an autopsy study of peritoneal dialysis (PD) patients with severe peritoneal HV lesions. Uremia is a systemic condition and, if capable of inducing HV, it will be expected to be detected outside the peritoneum. Seven autopsy cases of PD patients showing prominent peritoneal HV lesions were selected. Histological slides from the peritoneum, abdominal organs, heart and pericardium, lungs, visceral pleura, and central nervous system were reviewed. Peritoneal lesions were intense in all patients with prominent HV, fibrosis, and a variable presence of inflammation, fibrin, and calcification. Except for focal HV lesions in the intestinal submucosa of one diabetic patient, HV lesions were limited to the peritoneal membrane. None of the other extraperitoneal tissues showed such lesions. In conclusion, extraperitoneal vessels of PD patients show no relevant HV lesions when compared to peritoneal ones. This observation suggests that PD-related factors are the main contributors to the severity of vasculopathy. Uremia may participate in the development of the lesion but it does not seem to be responsible for its severity.
José A Jiménez-Heffernan; Cristian Perna; M Auxiliadora Bajo; M Luz Picazo; Gloria Del Peso; Luiz Aroeira; Abelardo Aguilera; Eva Tejerina; Manuel López-Cabrera; Rafael Selgas
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2008-05-07
Journal Detail:
Title:  Pathology, research and practice     Volume:  204     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
Department of Pathology, University Hospital, Puerta de Hierro, Madrid, Spain.
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MeSH Terms
Calcinosis / etiology,  pathology*
Hyalin / metabolism*
Middle Aged
Peritoneal Dialysis / adverse effects*
Peritoneum / blood supply*
Risk Factors
Severity of Illness Index
Uremia / complications,  pathology
Vascular Diseases / etiology,  metabolism,  pathology*

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