Document Detail


Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.
MedLine Citation:
PMID:  15567169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ABC transporter family. The purpose of this study was to quantify Bcrp mRNA in rat and mouse tissues, and to determine whether there are gender differences in Bcrp mRNA expression. Rat Bcrp mRNA levels were high in intestine and male kidney, and intermediate in testes. Mouse Bcrp expression was highest in kidney, followed by liver, ileum, and testes. Male-predominant expression of Bcrp was observed in rat kidney and mouse liver. Furthermore, gonadectomy and hypophysectomy experiments were conducted to determine whether sex steroids and/or growth hormone are responsible for Bcrp gender-divergent expression patterns. Male-predominant expression of Bcrp in rat kidney appears to be due to the suppressive effect of estradiol, and male-predominant expression of Bcrp in mouse liver appears to be due to the inductive effect of testosterone.
Authors:
Yuji Tanaka; Angela L Slitt; Tyra M Leazer; Jonathan M Maher; Curtis D Klaassen
Related Documents :
12072429 - Characterization of rat ndrg2 (n-myc downstream regulated gene 2), a novel early minera...
24633159 - Chalk5 encodes a vacuolar h(+)-translocating pyrophosphatase influencing grain chalkine...
19019169 - Effect of aggregated immunoglobulin a1 from immunoglobulin a nephropathy patients on ne...
23627939 - Hypoxia inducible factor stabilization as a novel strategy to treat anemia.
11095009 - Expression of complement regulatory proteins in the developing human kidney.
8794449 - Gene regulation of senescence marker protein-30 (smp30): coordinated up-regulation with...
17412869 - Comparative proteomic analysis for the detection of biomarkers in pancreatic ductal ade...
10777209 - B-atf functions as a negative regulator of ap-1 mediated transcription and blocks cellu...
12211169 - Platelet-derived growth factor a (pdgf-a) expression during zebrafish embryonic develop...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  326     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-11-29     Completed Date:  2005-02-03     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / metabolism*
Animals
Castration
Estradiol / pharmacology*
Female
Hormone Replacement Therapy / methods
Hypophysectomy
Male
Mice
Mice, Inbred C57BL
Organ Specificity / drug effects
Ovariectomy
Rats
Rats, Sprague-Dawley
Sex Factors
Species Specificity
Testosterone / pharmacology*
Tissue Distribution / drug effects
Grant Support
ID/Acronym/Agency:
ES-07079/ES/NIEHS NIH HHS; ES-09714/ES/NIEHS NIH HHS; F32 ES011239/ES/NIEHS NIH HHS; F32 ES011239-01/ES/NIEHS NIH HHS; F32 ES011239-02/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Abcg2 protein, rat; 3XMK78S47O/Testosterone; 4TI98Z838E/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathwa...
Next Document:  Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium...