| Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. | |
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MedLine Citation:
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PMID: 15567169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ABC transporter family. The purpose of this study was to quantify Bcrp mRNA in rat and mouse tissues, and to determine whether there are gender differences in Bcrp mRNA expression. Rat Bcrp mRNA levels were high in intestine and male kidney, and intermediate in testes. Mouse Bcrp expression was highest in kidney, followed by liver, ileum, and testes. Male-predominant expression of Bcrp was observed in rat kidney and mouse liver. Furthermore, gonadectomy and hypophysectomy experiments were conducted to determine whether sex steroids and/or growth hormone are responsible for Bcrp gender-divergent expression patterns. Male-predominant expression of Bcrp in rat kidney appears to be due to the suppressive effect of estradiol, and male-predominant expression of Bcrp in mouse liver appears to be due to the inductive effect of testosterone. |
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Authors:
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Yuji Tanaka; Angela L Slitt; Tyra M Leazer; Jonathan M Maher; Curtis D Klaassen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 326 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-11-29 Completed Date: 2005-02-03 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 181-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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metabolism* Animals Castration Estradiol / pharmacology* Female Hormone Replacement Therapy / methods Hypophysectomy Male Mice Mice, Inbred C57BL Organ Specificity / drug effects Ovariectomy Rats Rats, Sprague-Dawley Sex Factors Species Specificity Testosterone / pharmacology* Tissue Distribution / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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ES-07079/ES/NIEHS NIH HHS; ES-09714/ES/NIEHS NIH HHS; F32 ES011239-01/ES/NIEHS NIH HHS; F32 ES011239-02/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Abcg2 protein, rat; 50-28-2/Estradiol; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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