| Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction. | |
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MedLine Citation:
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PMID: 9245969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Evaluation of the tissue distribution of manganese (Mn) and general safety in normal and cholestatic male beagle dogs after i.v. administration of mangafodipir trisodium (MnDPDP, Teslascan). MATERIAL AND METHODS: Male beagle dogs, with or without surgical obstruction of the common bile duct, received a single i.v. bolus injection of saline (control), or MnDPDP at doses of 10 or 50 mumol/kg b.w. and were sacrificed 1 or 7 days after treatment. Toxicity was assessed and tissue concentrations of Mn were measured. RESULTS: Increased tissue Mn concentrations were found in all dogs treated with MnDPDP and were greatest in those with biliary obstruction. Although Mn concentrations decreased with time in most tissues in each of the treated groups, this was not the case for the brain and adrenal glands in dogs with total biliary obstruction in which further increases in Mn concentrations were seen at the later time point. This suggested a re-distribution of Mn from the major body depots such as the liver. There were no effects of MnDPDP on clinical signs/behaviour, organ weights, histomorphology or clinical biochemistry. CONCLUSION: These findings indicate that a single clinical dose of 5 mumol/kg MnDPDP is likely to be well tolerated in patients with cholestasis. |
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Authors:
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D Grant; K G Toft; I Martinsen; E Atzpodien |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 38 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-08-28 Completed Date: 1997-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 732-9 Citation Subset: IM |
Affiliation:
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Nycomed Imaging AS, Oslo, Norway. dgr@nycomed.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholestasis, Extrahepatic / diagnosis, metabolism* Common Bile Duct* / pathology Contrast Media / adverse effects, pharmacokinetics* Disease Models, Animal Dogs Drug Evaluation, Preclinical Edetic Acid / adverse effects, analogs & derivatives*, diagnostic use, pharmacokinetics Ligation Magnetic Resonance Imaging Male Manganese / adverse effects, diagnostic use, pharmacokinetics* Prognosis Pyridoxal Phosphate / adverse effects, analogs & derivatives*, diagnostic use, pharmacokinetics Safety Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 7439-96-5/Manganese |
| Comments/Corrections | |
Comment In:
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Acta Radiol. 1997 Jul;38(4 Pt 2):623-5
[PMID:
9245954
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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