Document Detail


Tissue distribution of exaprolol in rat.
MedLine Citation:
PMID:  2863149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The disposition of the beta adrenoceptor blocking drug 1-(2-cyclohexylphenoxy)-3-isopropylamino-2-propanol, exaprolol, in organs of the rat has been studied. After i.v. administration of 3H-exaprolol a transient extremely high accumulation of the drug in lungs was observed with a peak of 7.7% of dose/g 30 min post-administration. The disposition pattern in heart, kidneys and liver may be characterized by a tissue to plasma ratio about ten. Lower exaprolol tissue levels were observed after oral administration. The tissue to plasma ratios showed an initial increase followed by constant levels. The distribution of exaprolol in organs of the rat is discussed in the light of the previously determined pharmacokinetic parameters.
Authors:
V Faberová; T Trnovec; M Zemánek; S Bezek; M Durisová; O Tomcíková
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of drug metabolism and pharmacokinetics     Volume:  10     ISSN:  0378-7966     ISO Abbreviation:  Eur J Drug Metab Pharmacokinet     Publication Date:    1985 Jan-Mar
Date Detail:
Created Date:  1985-10-07     Completed Date:  1985-10-07     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  7608491     Medline TA:  Eur J Drug Metab Pharmacokinet     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  11-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adrenergic beta-Antagonists / metabolism*
Animals
Biotransformation
Injections, Intravenous
Kinetics
Male
Propanolamines / metabolism*
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 55837-19-9/exaprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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