| Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin. | |
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MedLine Citation:
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PMID: 9832465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uroguanylin, a member of the guanylin peptide family, acts on guanylyl cyclase C (GC-C) to regulate intestinal and renal fluid and electrolyte transport through the second messenger, cGMP. Using an antiserum raised against synthetic rat uroguanylin, we established an RIA and identified three endogenous molecular forms in the intestine and kidney: a 15-amino acid uroguanylin, an 18-amino acid uroguanylin that is a monobasic processing product, and a 9.4-kDa prouroguanylin. Prouroguanylin is the major molecular form in these two tissues, whereas only 15-amino-acid uroguanylin is present in the urine. Rat uroguanylin is most abundant in the proximal small intestine, its content decreasing toward the colon. Uroguanylin is present immunohistochemically in the endocrine cells in the intestine and stomach, B cells in the pancreatic islets, and tubular epithelial cells in the kidney. Uroguanylin has a widespread tissue distribution and is located in cells that function in an endocrine, paracrine, and/or luminocrine (luminal secretion) fashion. Uroguanylin may have physiological functions other than the regulation of fluid and electrolyte transport in the intestine and kidney. |
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Authors:
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M Nakazato; H Yamaguchi; Y Date; M Miyazato; K Kangawa; M F Goy; N Chino; S Matsukura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 139 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1998-12-24 Completed Date: 1998-12-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5247-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan. nakazato@post.miyazaki-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Chromatography, Affinity Chromatography, High Pressure Liquid Immunohistochemistry Intestines / cytology, metabolism Isomerism Male Molecular Sequence Data Natriuretic Peptides Osmolar Concentration Peptides / chemistry*, genetics, isolation & purification, metabolism* Radioimmunoassay Rats Rats, Sprague-Dawley Tissue Distribution Urine / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides; 0/Peptides; 152175-68-3/uroguanylin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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